Determination of igA antibody levels against tissue
transglutaminase.
The test is performed to diagnose celiac disease (this
visceral disease with a genetic basis characterized by
Intolerance to gluten - a protein contained in wheat, rye,
barley and contaminated oats).
In celiac disease, gluten has a toxic effect causing villous atrophy
intestinal villi.
The presence of IgA antibodies almost unequivocally confirms the
disease. In the absence of IgA antibodies with concomitant symptoms
suggestive of celiac disease (abdominal pain and bloating, diarrhea
fatty or watery diarrhea, weight loss, developmental abnormalities in
children, short stature, change in disposition, depression, deficiencies)
further diagnosis is necessary.